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KMID : 1143420180110130384
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Public Health Weekly Report
2018 Volume.11 No. 13 p.384 ~ p.391
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A longitudinal study on the patients and renal survival by specific causes of the chronic kidney disease in Korea
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Lee Kang-Hee
Yeom Hyung-Seon
Kim Kyoung-Hwa
Ahn Curie
Oh Kook-Hwan
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Abstract
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Background: Chronic kidney disease (CKD) is a rapidly growing disease and the prevalence of CKD in Korea is estimated to be around 13.7% of adult population. CKD is not only leads to dialysis or kidney transplantation but also a major threat to cardiovascular mortality. The goals of the present cohort study are to establish a CKD cohort representing Korean CKD population, and 2) to investigate the renal progression, mortality, complications, risk factors, role of biochemical arameters and the genetic influence. For these purposes, large-scale CKD cohort, comprising both adult and children, was established.
Methods: CKD cohort study was composed of KNOW-CKD sub-cohort for adult, KNOW-pedCKD sub-cohort for children and KNOW-KT sub-cohort for kidney allograft recipients. With a research network encompassing 17 institutions, a biobank was established for the sampling, safe transport and stocking of the DNA, serum and urine. Moreover, web-based case-report forms (CRF) were developed for the systemic management of the patient data including health questionnaires, consent forms, case-report forms, follow-up forms.
Results: Among 3,755 CKD cohort participants eligible at the baseline analysis, 3,271 was followed-up to date for analysis. Patients with diabetic nephropathy and hypertensive nephropathy were older and were presenting with more severe comorbidity than those with glomerulonephritis and polycystic kidney disease. The mortality rates per 1,000 person-year were 9.2 in the KNOW-CKD sub-cohort and 2.7 in the KNOW-pedCKD sub-cohort. The incidence rates of cardiovascular disease per 1,000 person-year were 18.9 in the KNOW-CKD sub-cohort and 0.8 in the KNOW-pedCKD sub-cohort.
Conclusion: This CKD cohort is expected to provide valuable information regarding the clinical evidence of CKD and also useful data for national health policy in Korea.
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KEYWORD
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Chronic kidney disease, Prevalence, Longitudinal studies, Diabetic nephropathy, Hypertensive nephropathy
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